Get to Know Us
Our goal is to integrate computational tools and novel technologies to enable unprecedented insights into molecular signaling circuits of cells in healthy and diseased tissues. We aim to push the boundaries of medicine and translate findings into clinical relevance such as in novel therapeutic approaches.
High-throughput single cell genomics allow us to characterize cellular identity and circuits on different molecular levels (DNA, RNA and protein).
Furthermore, we are working on predicting the future direction of cellular differentiation based on this data.
Cellular function depends on the tissue context. Novel technologies allow us to generate and analyze molecular data of cells in tissues at the single molecular level. With this we aim to characterize the cells in their native tissue environment. This includes information about where in the cells the molecules are located and thee general cellular phenotype like its size and shape.
In order to validate molecular circuits we utilize CRISPR-Cas screens which allow us to test the outcome of multiple gene perturbation on several target genes.
This also allows us to document molecular events, encoded in the genetic code, and to analyze this information via single-cell genomics at a later time
Multicellular complex 3D cell culture models like human iPSC-derived organoids help us to validate nodes of identified disease-relevant circuits.
We aim to combine cell imaging and molecular information in order to capture trajectories over defined time points.
For donations to help develop novel therapeutics for the worldwide growing population suffering from chronic kidney disease and chronic heart failure please contact Dr. Kuppe directly via email.
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